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The p53 protein is implicated in over 50% of human cancers (Lane). When it mutates, it ceases to be able to perform its native function: killing damaged cells, leading to uncontrolled cell growth—the hallmark of cancer. Therefore finding a way to return p53 from its mutant state to its native state is of the utmost importance. Engineering a molecule to rescue proteins requires atomic level information which is not available from wet lab studies. Computer science plays a critical role in this problem that Molecular Biology cannot: utilizing new advancements in high performance computing to produce high throughput models that produce cheaper and faster results, with atomic level resolution to explain the underlying mechanics. Allostery can broadly be defined as: one molecule binds to another macromolecule which modulates the binding behavior at a site distinct from the location of the binding event. An allosteric network is a system of residues that can communicate a signal across a protein from one site to another distinct site. Our lab hypothesizes that a network of motionally covarying residues, known as the sector, could send an allosteric signal to reactivate mutant p53.</p>"},{"label":"Group","value":["Theses & Dissertations"]},{"label":"Digital Origin","value":["born digital"]},{"label":"Discipline","value":["Computer Science","College of Integrative Sciences"]},{"label":"Date","value":"April 15, 2025"},{"label":"EDTF Date","value":"D:00 M:00 Y:2025"},{"label":"File Format","value":["application/pdf"]},{"label":"Digital Object Identifier (DOI)","value":"https://doi.org/10.14418/wes01.1.3159"},{"label":"Type","value":["Text"]}],"description":"Sector analysis of the p53 tumor suppressor 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