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Our results reveal that algebraic connectivity serves as a strong predictor of epidemic vulnerability, while Fiedler vectors identify critical nodes whose infection status disproportionately affects disease spread. We develop a network-based SIR model incorporating geospatial distance decay, population density, and road connectivity to simulate realistic epidemic scenarios. Comparative analysis across seven seeding strategies shows that spectral centrality measures outperform traditional degree-based metrics in predicting high-impact initial infections. This work provides both theoretical insights into the spectral determinants of epidemic dynamics and practical tools for data-driven public health intervention planning. Future work will validate the model and examine alignment with empirical data."},{"label":"Publication Information","value":"Copyright for this work is retained by the authors. 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