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In this study only main effects are taken into consideration. Moreover, by making a quasi-steady state approximation the model is reduced to a single nonlinear differential equation of which parameters are fit to data from healthy subjects. Feedback provided by insulin plays a key role in the control of the blood glucose level. Reduced β-cell function and insulin resistance may hamper this process. With the present model it is shown how by closed-loop control these defects, in an organic way, can be compensated with continuous infusion of exogenous insulin."},{"label":"DOI","value":"10.1371/journal.pone.0169135"},{"label":"Volume","value":"12"},{"label":"Issue","value":"1"},{"label":"Publication Date","value":"D:01 M:06 Y:2017"},{"label":"Publication Information","value":"© 2017 Grasman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Archived version is the final published version."}],"description":"Proportional Insulin Infusion in Closed-Loop Control of Blood Glucose","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://iiif.quartexcollections.com/portland/iiif/a19eed83-ac6a-48ab-be38-e0c4284b8f7b/canvas/_1","@type":"sc:Canvas","label":"Proportional Insulin Infusion in Closed-Loop Control of Blood 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