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The most common treatments currently are insulin pumps, continuous glucose monitoring and diet regulation. There is a need for a treatment that goes beyond constant insulin regulation; a long-term cure that will allow those with diabetes to produce their own insulin. One such treatment focuses on replacing the lost insulin is the transplantation of donor or stem cell islets, although studies show that insulin independence from this treatment currently maxes out at two to three years. Transplantation of autologous or donor islets raises many immunological challenges, including antibody-mediated rejection which can be mediated by several solutions (Kabakchieva et al., 2023). One specific solution is immunosuppression; by decreasing the immune response to the transplantation it is more likely to not be rejected by the patient's immune system. However, by doing so the patient is at risk of acute immune responses as well as a decreased success rate (Kabakchieva et al., 2023). There is a need to improve immunological factors before transplantation and fecal microbiota transplantation could be the solution. Studies show that fecal microbiota transplantation (FMT) boosts beneficial bacteria in the gut promoting stronger immune function, balancing out the eventual secondary effects of immunosuppression (Taur et al., 2018).\nThis paper explores the potential of fecal microbiota transplantation as a therapeutic strategy to restore gut microbiota balance, enhance the immune response, and improve long-term insulin production outcomes for patients undergoing islet cell transplantation in T1DM."},{"label":"Publication Information","value":"BIO 410: Advances in Biomedical Science\nCopyright for this work is retained by the authors."},{"label":"Faculty Advisor","value":["Dr. Susan Murray"]},{"label":"College & School","value":["College of Arts and Sciences"]},{"label":"Department","value":["Biology"]},{"label":"Is Part Of","value":["Office of Undergraduate Scholarly Engagement"]},{"label":"Document Type","value":["Honors project"]},{"label":"Undergraduate Collection","value":["Biology Student 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