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Matrix metalloproteinases 2 and 9 (MMP2/9) have generally been found to degrade components of the vascular extracellular matrix (ECM), thereby clearing a path for smooth muscle cells (SMCs) to migrate. However, little is known about how MMP2/9 activity impacts CA SMC development. We microinjected chlorotoxin (an MMP2 antagonist) and JNJ0966 (an MMP9 antagonist) into the pericardial space of developing chick embryos, analyzing CA diameter and SMC expression to determine the role of MMP2 and MMP9. Inhibition of either extracellular matrix enzyme led to a significant difference in smooth muscle alpha-actin expression between treated and control embryos (p < 0.01, two-way ANOVA; n = 9 vehicle control embryos and n = 17 JNJ-injected embryos). MMP9 inhibition additionally led to abnormal coronary artery phenotype when SMC expression was absent. An understanding of the role of MMPs in SMC migration during CA development may help prevent or reverse coronary artery anomalies and could contribute to strategies aimed at regenerating cardiac tissue after ischemic injury. This project was funded by NIH R15 HL167279-01 (LAD)."},{"label":"Publication Information","value":"Copyright for this work is retained by the author. BIO 487: OTPT Capstone"},{"label":"Faculty Advisor","value":["Dr. Laura Dyer"]},{"label":"College & School","value":["College of Arts and Sciences"]},{"label":"Department","value":["Biology"]},{"label":"Is Part Of","value":["Office of Undergraduate Scholarly Engagement"]},{"label":"Document Type","value":["Honors project"]},{"label":"Undergraduate Collection","value":["Biology Student Works"]}],"description":"MMP2 and MMP9 Inhibition Disrupts Smooth Muscle Cell Recruitment to the Developing Coronary Artery","sequences":[{"@type":"sc:Sequence","canvases":[{"@id":"https://iiif.quartexcollections.com/portland/iiif/279d2f29-2af1-4b48-8790-701c3fe54ba0/canvas/_1","@type":"sc:Canvas","label":"William 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