{"@context":"http://iiif.io/api/presentation/2/context.json","@type":"sc:Manifest","@id":"https://iiif.quartexcollections.com/berry/iiif/fa545776-96fd-472f-a56c-a39964d07bec/manifest","label":"McCauslandCalista_2025_Honors","metadata":[{"label":"Identifier","value":"McCauslandCalista_2025_Honors"},{"label":"Committee Chair","value":["Delwarence J. Sykes"]},{"label":"Degree","value":["Bachelor of Science"]},{"label":"Project Type","value":["Thesis"]},{"label":"Research Funding Link","value":"Learn more about <a href=\"https://berry.edu/academics/faculty-resources/undergraduate-research/summer-research\" target=\"_blank\"> summer research. </a>"},{"label":"Research Funding","value":["Summer Undergraduate Research Fellowship"]},{"label":"Author Supplied Keywords","value":"behavioral research, animal research, inflammatory bowel disease, colitis, cytokine presence"},{"label":"Author","value":["Calista McCausland"]},{"label":"School","value":["School of Mathematical and Natural Sciences"]},{"label":"Subject","value":["Inflammatory bowel diseases","Animal behavior--Research"]},{"label":"Access Restrictions","value":["immediate unrestricted access"]},{"label":"Rightsholder","value":["Calista McCausland"]},{"label":"Rights Link","value":"<a href=\"https://rightsstatements.org/page/InC/1.0/?language=en\" target=\"_blank\"> In Copyright</a>"},{"label":"Rights","value":["In Copyright"]},{"label":"Decade","value":["2020s"]},{"label":"Type","value":["Text"]},{"label":"Holding Institution","value":["Berry College"]},{"label":"Extent","value":"17 pages"},{"label":"Medium","value":["theses"]},{"label":"Publisher","value":["Berry College"]},{"label":"Language (DLG)","value":["eng"]},{"label":"Language","value":["English"]},{"label":"Format","value":["application/pdf"]},{"label":"Description","value":"Inflammatory Bowel Disease (IBD) affects over 1.6 million Americans annually and includes Crohn’s Disease and Ulcerative Colitis. Chronic stress can increase the incidence of depression- and anxiety-like behavior and may exacerbate gastrointestinal conditions like IBD. This study investigated whether the chronic stress of social isolation worsens IBD. Following 30 days of social isolation, Dextran Sulfate Sodium Salt (DSS) was used to induce IBD in mice. We hypothesized that socially isolated mice would show more anxiety- and depression-like behavior and have shorter colon lengths compared to controls. Behavioral tests (Open Field Test: OFT and Forced Swim Test: FST) reflect mixed effects of social isolation on behavior. OFT results showed that isolated mice had reduced anxiety-like behavior as measured by a reduction in exploration of the open field maze (Welch’s Two Sample t-test P<0.01). Conversely, we found no difference in depression-like behavior as measured by the FST (Welch’s Two Sample t-test P>0.05). We found a significant effect of DSS treatment on colon length when measured post-mortem (Ordinary One-Way ANOVA P<0.0001). DSS-treated mice had shorter colons than water controls; however, isolation did not affect colon length (Tukey’s multiple comparisons P>0.05). This study revealed that chronic stress increases incidences of anxiety- and depression-like behavior."},{"label":"Date","value":"May 9 2025"},{"label":"Date (Filter)","value":"D:09 M:05 Y:2025"},{"label":"Creator","value":["Calista McCausland"]},{"label":"Title","value":"Chronic Stress and IBD-Like Colitis in Mice: \n\n Effects of Social Isolation on Behavior and Disease Severity"},{"label":"Faculty Advisor","value":["Christopher Hall"]},{"label":"Major","value":["Biochemistry"]}],"description":"Chronic Stress and IBD-Like Colitis in Mice: \n\n Effects of Social Isolation on Behavior and Disease 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